Proportion of CD4 cells before and after antiretroviral therapy (ART) in people living with HIV/AIDS visiting ART center in Sukraraj Tropical and Infectious Disease Hospital, Teku, Kathmandu, Nepal
Abstract
The present study deals with effect of antiretroviral treatment (ART) and effect of antiretroviral drugs (ARV) on clients attending the ART and Voluntary counseling and testing center (VCT). It is a prospective cross-sectional record-based study. According to the present study, 78 clients have taken ART age up to 54 years. Out of 78 positives, 45 (57.69%) were males and 33 (42.30%) were females. The result showed no significant relationship between age and gender (χ2=4.196, P>0.05) of HIV positives taking ART. Majority of the positives taking ART have CD4 count less than 350 cells/mm3 of blood and no significant relation was found between the number of positives taking ART and the CD4 cell count (χ2=40, P>0.05). Majority of the positives i.e. 38 (48.7%) were on the WHO stage II. Majority of the positives i.e. 55 (70.5%) were given ART regimen containing Zidovudine (ZDV), Lamivudine (3TC) and Nevirapine (NVP). The mean rise of CD4 cells i.e. 368.79 cells/µl of blood after 6 months of ART was found significant to initial CD4 count (P<0.05). Hence significant relationship was established between the ART and the increase in CD4 count (V= 8.046 P<0.05). It is also found that there is a significant increase in
CD4 counts in both NVP and EFV group in unit increase of time (i.e. 6 months) (p<0.05). Also there was a significant increase (P<0.05) in weight of the positives after 6 months of ART.
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