Autoimmune Diseases: An Introduction
Abstract
The immune system recognizes and eliminates foreign agents, and protects the host against infection. Autoimmunity is a natural phenomenon where self-reactive antibodies and autoimmune cells are present in all individuals. A combination of genetic predisposition and environmental factors contribute to the development of autoimmune diseases. Autoantibodies attack structures within individuals that produce them. Autoimmunity is a major cause for a number of serious and fatal diseases. Presence of one autoimmune disease increases the chance for simultaneously developing other autoimmune diseases in the same person.
References
Abbas, A. K., Lohr, J., Knoechel, B. andNagabhushanam, V. 2004.T cell tolerance and autoimmunity. Autoimmunity Reviews,3: 471–475.
Dale, R. C. 2003. "Acute disseminated encephalomyelitis". SeminPediatr Infect Dis, 14 (2): 90–5.
De Groot, P. G., Meijers, J. C. and Urbanus, R. T. 2012. Recent developments in our understanding of the antiphospholipid syndrome. Int J Lab Hematol,34 (3):223-31.
Fairweather, D. and Rose N. R. 2004.Women and autoimmune diseases.Emerging. Infectious Diseases, 10: 2005–2011.
Fairweather, D. and Rose, N. R. 2005. Inflammatory heart disease: a role for cytokines. Lupus 14 (9):646–651.
Feldmann, M. andMaini, R. N. 2003.Lasker clinical medical research award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nature Medicine,9: 1245–1250.
Garg, R. K. 2003. "Acute disseminated encephalomyelitis". Postgrad Med J, 79 (927): 11–7.
Goodnow, C. C., Sprent, J., Fazekas de St.Groth, B. andVinuesa, C. G. 2005.Cellular and genetic mechanisms of self-tolerance and autoimmunity.Nature,435: 590–597.
Huynh, W., Cordato, D. J., Kehdi, E., Masters, L.T. andDedousis, C. 2008. "Post-vaccination encephalomyelitis: literature review and illustrative case". J ClinNeurosci,15 (12): 1315–1322.
Jones, C. T. 2003. "Childhood autoimmune neurologic diseases of the central nervous system".NeurolClin, 21 (4): 745–64.
Nelson, B. H. 2004. IL-2, regulatory T cells, and tolerance. Journal of Immunology, 172: 3983–3988.
Rose, N. R and Mackay, I. R. (eds) 2006. The Autoimmune Diseases, 4thedn. London: Elsevier Academic Press.
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